CD74 is expressed on the surface of renal tubular epithelial cells. Also, these cells Convey minimal amounts of MIF that is increased subsequent AKI to make certain ample provides at the location of damage (eighty, eighty one). A spontaneous pathological renal phenotype is absent MIF knock-out mice, suggesting tiny to no impact on nutritious organs (eighty two). even so, substantial MIF concentrations can be found within the serum of clients next cardiac surgical procedure and correlates with defense from AKI (81).
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